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Ann Pediatr Endocrinol Metab > Volume 17(1); 2012 > Article
Serum Alkaline Phosphatase Levels in 10-20 Year Old Healthy Korean Children and Adolescents: Based on the 2009 Korean National Health and Nutrition Examination Survey.
Ji Young Seo, Jeong Don Chae, Hong Kyu Park, Dong Ho Kim, Jun Ah Lee, Jung Sub Lim
1Department of Pediatrics, Eulji Hospital, Eulji University School of Medicine, Seoul, Korea.
2Laboratory Medicine, Eulji Hospital, Eulji University School of Medicine, Seoul, Korea.
3Department of Pediatrics, Ajou University School of Medicine, Suwon, Korea.
4Department of Pediatrics, Korean Cancer Center Hospital, Seoul, Korea.
Serum alkaline phosphatase (sALP) levels show great variation with age and sex in children and adolescents. We aimed to study pediatric age- and sex-specific reference ranges for sALP and how the pattern changed according to age . METHODS: Cross-sectional results from 1366 healthy Korean children and adolescents (10-19.9 years) from the Korean National Health and Nutrition Examination Survey were analyzed. We constructed age- and sex-specific reference data for sALP with a Hitachi Automatic Analyzer 7600 using Pureauto S ALP. We assessed its peak both in relation to age.
Reference values for sALP according to age were constructed. Peak sALP levels were found at 12-13 years in boys (P < 0.001). Total sALP levels decreased to the adult level at the age of 17 in boys and 15 in girls, respectively.
This study provides reference values for sALP by age for Korean children and adolescents. This normative data that includes upper and lower limits will provide a basis from which to better evaluate sALP levels, especially for bone disorders such as rickets and vitamin D deficiency. However, caution should be made in interpreting sALP levels because different buffers might lead to different values in the same serum.
Keywords: Alkaline phosphatase;Reference values;Korean;Child;Adolescent;Sex characteristics


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