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Ann Pediatr Endocrinol Metab > Accepted Articles
DOI: https://doi.org/10.6065/apem.2040268.134    [Accepted] Published online May 20, 2021.
Effects of gonadotropin-releasing hormone agonist treatment on final adult height in boys with idiopathic central precocious puberty
Ah Young Cho1  , Su Yeong Ko2, Jae Hee Lee3, Eun Young Kim1 
1Department of Pediatrics, Chosun University Hospital, Gwangju, Korea
2I-Mom Children & Adolescent
3Department of Pediatrics, Chungbuk National University Hospital, Chungju, Korea
Address for correspondence:  Eun Young Kim
Email: sskey@chosun.ac.kr
Received: December 2, 2020   Revised: February 19, 2021   Accepted: February 23, 2021
Abstract
Purpose
There are few reports on the therapeutic effects of gonadotropin-releasing hormone agonists in boys with central precocious puberty, and no studies have been reported in Korea. We aimed to assess the significance of clinical factors and the effects of gonadotropin-releasing hormone agonist treatment on final adult height in boys diagnosed with central precocious puberty.
Methods
We retrospectively evaluated the medical records of 18 boys treated for idiopathic central precocious puberty between 2007 and 2018 at Chosun University Hospital. Gestational age, birth weight, and parental height were assessed at the initial visit. Chronological age, bone age, bone age/chronological age ratio, height and height standard deviation scores, predicted adult height, body mass index, and hormone levels were assessed during the treatment period.
Results
At the time of diagnosis, the chronological age was 9.9±0.6 years, the bone age was 11.6±1.0 years, and the bone age/chronological age ratio was 1.20±0.1. The bone age/chronological age ratio decreased significantly to 1.12±0.1 at the end of treatment (P<0.05). The luteinizing hormone/follicular stimulating hormone ratio was 3.4±1.2, 0.6±0.4, 0.6±1.0 at the start of treatment, after 1 year of treatment, and at the end of treatment, respectively. After gonadotropin-releasing hormone agonist treatment, the final adult height reached 172.0±4.8 cm into the range of target height of 171.0±4.0 cm.
Conclusion
In boys with central precocious puberty, gonadotropin-releasing hormone agonist treatment improved growth potential.
Keywords: Precocious puberty; Gonadotropin-releasing hormone; Boy


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