J Korean Soc Pediatr Endocrinol Search


Ann Pediatr Endocrinol Metab > Volume 13(2); 2008 > Article
Long-term Follow-up Outcome in Children and Adolescents with Hashimoto's Thyroiditis.
Jung Hyun Lee, Han Wook Yoo
1Department of Pediatrics, Kosin University College of Medicine, Busan, Korea.
2Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. hwyoo@amc.seoul.kr
Hashimoto's thyroiditis is the most common cause of thyroid disease in children and adolescents. It shows a wide spectrum of thyroid functions, ranging from hypothyroidism to hyperthyroidism, with variable clinical course. This study was undertaken to investigate the clinical course and outcome of Hashimoto's thyroiditis with long-term follow-up in children and adolescents. METHODS: We analyzed retrospectively clinical data in 85 girls diagnosed as Hashimoto's thyroiditis in the pediatric endocrinology clinic at Asan Medical Center from January 1996 to June 2006. Of 24 patients, who had been followed up for more than five years, we investigated age at diagnosis, family history, initial thyroid function, initial thyroid autoantibody titers, changes of thyroid function, and changes of positivity rate of thyroid autoantibody.
The mean age at diagnosis was 10.9+/-2.6 years. Goiter was found in about 95% of patients, whereas 5 patients presented with short stature. Positive family history of autoimmune thyroid disease was documented in 27 out of 85 patients (31.8%). At diagnosis, 34 of 85 patients (40.0%) were in euthyroidal status, 43 (50.7%) in overt or compensated hypothyroidism, and 8 (9.4%) in hyperthyroidism. Among the 24 patients followed up for more than five years, 7 patients were in euthyroidal status, 16 in overt or compensated hypothyroidism, and 1 in hyperthyroidism at initial presentation. Four patients initially diagnosed with euthyroidism remained in euthyroidal status, while 7 patients with hypothyroidism were shifted to euthyroidism. Overall, 15 out of 24 patients were in remission status at the last follow-up. Initial TSH level was significantly higher in non-remission group (P=0.016). Initial thyroid autoantibody titers were not correlated with remission rate.
The clinical course of children and adolescents with Hashimoto's thyroiditis varied widely. After more than five years follow-up, 62.5% of patients remained or became euthyroid. Initial TSH level can be a prognostic factor of Hashimoto's thyroiditis.


Browse all articles >

Editorial Office
501-107, 30 Seocho-daero 74-gil, Seocho-gu, Seoul 06622, Republic of Korea
Tel: +82-2-3471-4268    Fax: +82-2-3471-4269    E-mail: editor@e-apem.org                

Copyright © 2024 by Korean Society of Pediatric Endocrinology.

Developed in M2PI

Close layer
prev next