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Ann Pediatr Endocrinol Metab > Accepted Articles
DOI: https://doi.org/10.6065/apem.2142226.113    [Accepted] Published online June 28, 2022.
The association between C-reactive protein, metabolic syndrome, and prediabetes in Korean children and adolescents
Ji Hyun Kim1  , Jung Sub Lim2 
1Department of Pediatrics, Dongguk University Ilsan Hospital, Goyang, Korea
2Department of Pediatrics, Korea Cancer Center Hospital, Seoul, Korea
Address for correspondence:  Jung Sub Lim
Email: limjs@kcch.re.kr
Received: November 22, 2021   Revised: December 27, 2021   Accepted: February 23, 2022
Metabolic syndrome (MetS) is a state of chronic inflammation, and high-sensitivity C-reactive protein (hsCRP) indicates inflammation. This paper evaluates the association between hsCRP and MetS and its components in Korean children and adolescents.
We analyzed the data of 1,247 subjects (633 males, 14.2 ± 2.7 years) from the Korea National Health and Nutrition Examination Survey (KNHANES) 2016-2017. This study defined MetS and its components using the modified National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) criteria.
The mean hsCRP level was 0.86 ± 1.57 mg/dL (median and interquartile range: 0.37 and 0.43 mg/dL). Subjects with MetS had higher hsCRP levels than subjects without MetS (geometric mean: 1.08 vs. 0.46 mg/dL, P<0.001). With the higher quartile value of hsCRP, the prevalence of MetS increased. Compared to the lowest quartile, the odds ratio (ORs) for having MetS in the highest quartile was 7.34 (3.07-17.55), adjusting for age and sex. In the top quartile of hsCRP, the risk of having abdominal obesity and low HDL was high after adjusting for age, sex, and other components of the MetS. Additionally, the ORs for having prediabetes (HbA1c ≥5.7%) in the highest quartile was 2.70.
Serum hsCRP level is positively associated with MetS and prediabetes even using NCEP-ATP III criteria. Among the MetS components, abdominal obesity and low HDL were highly correlated with hsCRP in Korean children and adolescents.
Keywords: Children and adolescents, Metabolic syndrome, hsCRP, Obesity, Prediabetes, KNHANES


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