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Ann Pediatr Endocrinol Metab > Volume 15(2); 2010 > Article
The Clinical Characteristics of Type 2 Diabetes Mellitus with and without beta-cell Autoantibody in Children and Adolescents.
Min Chul Ji, Hyun Wook Chae, Ho Seong Kim, Duk Hee Kim
Department of Pediatrics, Yonsei University College of Medicine, Severance Children's Hospital, Seoul, Korea. dhkim3@yuhs.ac
Abstract
PURPOSE
The aim of this study is to investigate the differences in clinical characteristics and disease process between autoantibody-positive and -negative patients with type 2 diabetes mellitus (DM). METHODS: We investigated 162 patients diagnosed as DM between January 2000 and July 2009. 120 were classified as type 1 and 42 as type 2 DM. The clinical and laboratory data were obtained from medical records, retrospectively.
RESULTS
The age at diagnosis, average BMI and serum C-peptide levels were significantly higher in type 2 DM patients than in type 1 DM patients. Type 2 DM patients had a significantly higher family history of diabetes and less frequent ketonuria. There were no significant differences between autoantibody-positive and -negative type 2 DM patients in age at diagnosis, BMI, C-peptide levels, HbA1c levels or family history. During the follow-up period, C-peptide levels were lower in the autoantibody-positive group than in the autoantibody-negative group, while. HbA1c levels were higher in the autoantibody-positive group. However, these differences were not statistically significant.
CONCLUSION
In autoantibody-positive type 2 DM patients, progressive loss of beta-cell function leads to reduced insulin secretion and poor glycemic control as the disease progresses, and some may be reclassified as slowly progressive type 1 DM. Ccntinued and careful follow-up is therefore needed.
Keywords: Diabetes mellitus, type 2;Autoantibodies;Child;Adolescent


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