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Ann Pediatr Endocrinol Metab > Volume 15(3); 2010 > Article
Predictive Factors of Diabetes and Hypertension in Adult Turner Syndrome.
Hye Young Jin, Jin Ho Choi, Beom Hee Lee, Han Wook Yoo
Division of Pediatric Endocrinology and Metabolism, Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea. jhc@amc.seoul.kr
Abstract
PURPOSE
The risk of cardiovascular diseases (CVD) including hypertension, artherosclerosis and endocrinologic diseases such as thyroid disease, obesity, diabetes mellitus are elevated in adult Turner syndrome (TS). Clinical and biochemical parameters of TS patients were analyzed to investigate the predictive factors of diabetes and hypertension. METHODS: Twenty nine patients with TS were enrolled in this study. Clinical and biochemical parameters including height, weight, body mass index (BMI), blood pressure, waist and hip circumferences, lipid profile, insulin, fasting glucose, and HbA1c were retrospectively reviewed.
RESULTS
Seven (24.1%) out of 29 had either impaired fasting glucose (IFG) or diabetes, 3 (10.3%) had central obesity, 5 (17.2%) had hypertriglyceridemia, 4 (13.8%) had low HDL cholesterol, 6 (20.7%) had hypertension, and 3 (10.3%) out of 29 were consistent with the criteria of MS. The waist circumference was longer in patients with either IFG or diabetes (67.1 +/- 5.4 cm vs. 79.4 +/- 8.3 cm, P = 0.009). Insulin, homeostasis model assessment-insulin resistance (HOMA-IR), and adipokine levels were not significantly different according to the presence of either IFG or diabetes. Among TS patients, BMI was higher in patients with hypertension (26.2 +/- 5.7 kg/m2 vs. 22.5 +/- 3.1 kg/m2, P = 0.042). Total cholesterol exhibited a significant difference between patients with hypertension and those without hypertension (177.3 +/- 29.6 mg/dL vs. 222.8 +/- 28.5 mg/dL, P = 0.004).
CONCLUSION
Adult TS patients should be carefully followed regarding the development of diabetes and hypertension in case of severe central obesity and dyslipidemia.
Keywords: Turner syndrome;Metabolic syndrome;Hypertension;Diabetes mellitus


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