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Ann Pediatr Endocrinol Metab > Volume 15(3); 2010 > Article
Growth Hormone Treatment for Fanconi Anemia with Growth Hormone Deficiency.
Min Kyoung Kim, Min Jae Kang, Hye Rim Chung, Choong Ho Shin, Sei Won Yang
1Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea. chshinpd@snu.ac.kr
2Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea.
Abstract
Short stature is common in case of Fanconi anemia (FA) and may result from inherent abnormalities of FA or endocrinopathies, such as a growth hormone deficiency and hypothyroidism. Growth hormone treatment in FA patients with growth hormone deficiency (GHD) has been controversial because FA itself has a risk of malignancy, and there has been a concern about the increased risk of malignancy from growth hormone treatment. We report on an FA boy with GHD who was diagnosed with FA and undertook stem cell transplantation. Because he showed severe growth failure, growth hormone therapy was initiated at 6 years of age, after he was diagnosed with hypopituitarism, including GHD. He expressed significant catch-up growth with no complications beyond the two year follow up period. This case suggests that growth hormone therapy can be considered in patients with GHD caused by FA, with careful monitoring for malignancy.
Keywords: Fanconi anemia;Growth hormone deficiency


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