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Ann Pediatr Endocrinol Metab > Volume 9(2); 2004 > Article
Two Cases of Transient Neonatal Diabetes Mellitus in Twin Brothers.
Jin Hyung Cho, Eon Woo Shin, Seung Yang, Eun Young Park, Kwang Nam Kim, Dae Yeol Lee, Phil Soo Oh
Abstract
Neonatal diabetes mellitus (NDM) is defined as hyperglycemia that presents clinical symptoms within the first month of life and requires insulin therapy to maintain euglycemia. The diabetic condition may be transient, permanent, or transient with recurrence later in life. NDM is a rare clinical disorder. Three cases of NDM have been reported in Korea so far. We experienced two cases of NDM in twin brothers who were born with small for gestational ages. Their HLA typings were DR9 and DR14, and insulin autoantibody, islet cell antibody, GAD-reactive autoantibody, and insulin receptor antibody were not found. The genetic analysis with polymorphic DNA markers for chromosome 6 indicated paternal uniparental isodisomy.
Keywords: Neonatal diabetes mellitus;Twin;Chromosome6;Uniparental disomy


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