Warning: mkdir(): Permission denied in /home/virtual/lib/view_data.php on line 81 Warning: fopen(/home/virtual/e-apem/journal/upload/ip_log/ip_log_2023-03.txt): failed to open stream: No such file or directory in /home/virtual/lib/view_data.php on line 83 Warning: fwrite() expects parameter 1 to be resource, boolean given in /home/virtual/lib/view_data.php on line 84 Slower progression to central puberty in overweight girls presenting with precocious breast development
J Korean Soc Pediatr Endocrinol Search


Ann Pediatr Endocrinol Metab > Accepted Articles
DOI: https://doi.org/10.6065/apem.2244062.031    [Accepted] Published online June 30, 2022.
Slower progression to central puberty in overweight girls presenting with precocious breast development
Eun-Gyong Yoo  , Mi Ra Kim  , Mo Kyung Jung 
Department of Pediatrics, CHA Bundang Medical Center, CHA University, Seongnam, Korea
Address for correspondence:  Eun-Gyong Yoo
Email: pedyoo@cha.ac.kr
Received: February 26, 2022   Revised: April 29, 2022   Accepted: May 9, 2022
Overweight/obese girls tend to have an earlier pubertal onset. However, only few studies on the progression of puberty in these girls are reported. This study aimed to identify risk factors for rapid pubertal progression in overweight/obese girls presenting with precocious breast development.
This retrospective cohort study reviewed the medical records of 110 overweight (OW, BMI >85P for age and sex) and 213 non-overweight (NW, BMI <85P for age and sex) girls who presented with breast budding before 8 years of age. OW girls were divided into two subgroups: girls with central puberty progression before 9 years of age (OW-RP) and those without (OW-SP).
Progression to central puberty before the age of 9 was more common in NW girls than in OW girls (83.8 % vs. 65.2 % in NW vs. OW group, P<0.001), and progression free survival for 1, 2, and 3 year were higher in the OW group (P<0.001). In subgroup analysis for OW girls, the OW-RP subgroup had more advanced bone age (BA) at first visit (P=0.047), and higher initial luteinizing hormone (LH, P=0.010) levels, compared to OW-SP subgroup. Being NW (P=0.001) as well as more advanced BA (P=0.023) at initial workup were the risk factors of pubertal progression before the age of 9.
Pubertal progression seems to be slower in OW girls presenting with precocious breast development than in those NW. However, it can progress rapidly in these girls with more pronounced BA advancement and higher LH levels at the initial workup.
Keywords: Puberty; precocious, Pediatric obesity, Overweight, Luteinizing hormone
Share :
Facebook Twitter Linked In Google+
METRICS Graph View
  • 0 Crossref
  • 694 View
  • 37 Download
Related articles in APEM


Browse all articles >

Editorial Office
#510, DoosanBearstel 381, Gangnam-daero, Seocho-gu, Seoul 06620, Korea
Tel: +82-2-3471-4268    Fax: +82-2-3471-4269    E-mail: kspe.editor@gmail.com                

Copyright © 2023 by Korean Society of Pediatric Endocrinology.

Developed in M2PI

Close layer
prev next