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Ann Pediatr Endocrinol Metab > Accepted Articles
DOI: https://doi.org/10.6065/apem.2142006.003    [Accepted] Published online May 20, 2021.
Three pediatric patients with primary hyperparathyroidism caused by parathyroid adenoma
Arum Oh1, Yena Lee2, Han-Wook Yoo2, Jin-Ho Choi2 
1Department of Pediatrics, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea
2Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea
Address for correspondence:  Jin-Ho Choi
Email: jhc@amc.seoul.kr
Received: December 18, 2020   Revised: March 22, 2021   Accepted: April 5, 2021
Primary hyperparathyroidism (PHPT) is disorder of hypercalcemia with inappropriately normal or increased serum parathyroid hormone (PTH) levels resulting from the excessive secretion of PTH from one or more of the parathyroid glands. PHPT is uncommon in infants and children, with an estimated incidence of 2–5 cases per 100,000 population. Patients with PHPT usually present with bone pain, urolithiasis, or nephrolithiasis, and nonspecific symptoms such as fatigue and weakness, notwithstanding, asymptomatic hypercalcemia may also be detected incidentally. Only a few cases of pediatric PHPT have been reported in Korea. We present three patients with PHPT who manifested variable clinical features of hypercalcemia. The first and second patients each had a parathyroid adenoma and presented with abdominal pain caused by pancreatitis and a ureter stone, respectively. The third patient had an ectopic mediastinal parathyroid adenoma and presented with gait disturbance and weakness in the lower extremities. All the patients underwent surgical resection of the parathyroid adenoma, and their serum calcium levels were subsequently normalized without medication.
Keywords: Hypercalcemia, Hyperparathyroidism, Parathyroid adenoma


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