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Ann Pediatr Endocrinol Metab > Volume 15(1); 2010 > Article
Biochemical Markers as Predicting Factor for Metabolic Bone Diseases in Very Low Birth Weight Infants.
Myo Jing Kim, Mi Jin Kim, Shin Yun Byun, Hae Jin Lee, Jae Ho Yoo
1Department of Pediatrics, College of Medicine, Dong-A University, Busan, Korea. pedendo@dau.ac.kr
2Department of Pediatrics, School of medicine, Pusan National University, Busan, Korea.
3Department of Pediatrics, ll-Sin Christian Hospital, Busan, Korea.
The aim of present study was to assess the utility of serum biochemical markers for predicting the metabolic bone disease (MBD) in very low birth weight infants (VLBWI). METHODS: Medical records of 104 VLBWI from 2003 to 2008 were reviewed in this retrospective study. Study patients were divided in MBD and control group according to the finding of wrist radiography performed at 4 weeks of life. We compared the serum biochemical markers including alkaline phosphate (ALP), calcium (Ca), phosphate (P) between two groups at birth, 1 and 4 weeks of life. The value of serum vitamin D (Vit. D) was measured at 4-5 weeks of life.
The mean gestational age and birth weight of study patients were 30(+6) +/- 2.0 weeks and 1,308.2 +/- 136.7 g. The incidence of MBD was 28.9% (31 / 104). At birth, higher values of serum ALP (438.1 +/- 129.1 mg/dL vs 360.5 +/- 122.8 mg/dL) were found in MBD group. At 1 week of life, higher values of serum Ca (11.0 +/- 1.7 mg/dL vs 10.3 +/- 1.7 mg/dL) and lower values of serum P (3.2 +/- 1.2 mg/dL vs 4.1 +/- 1.3 mg/dL) were found in MBD group. At 4 weeks of life, higher values of serum ALP activities (1,397.6 +/- 635.6 U/L vs 789.0 +/- 573.0 U/L), lower values of serum P (4.2 +/- 2.0 mg/dL vs 5.4 +/- 1.8 mg/dL) and Vit. D (17.7 +/- 7.2 ng/mL vs 30.0 +/- 15.5 ng/mL) were found in MBD group. Risk factors of MBD were male and Vit. D deficiency with high ALP at 4 weeks of life.
These results suggest that high ALP concentrations at 4 weeks of life may predict MBD with Vit. D deficiency in VLBWI.
Keywords: Bone diseases;Metabolic;Infant;Very low birth weight


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