A Case of Systemic Lupus Erythematosus with Graves Disease in a Child.

Kim,  Shin Hee; Yoon,  Kyung Lim; Lee,  Sang Ho; Won,  Kyu Yeoun; Shim,  Kye Shik

doi:2012.17.3.189

Ann Pediatr Endocrinol Metab > Volume 17(3); 2012 > Article

Case Report

Annals of Pediatric Endocrinology & Metabolism 2012;17(3): 189-193.

DOI: https://doi.org/10.6065/apem.2012.17.3.189

A Case of Systemic Lupus Erythematosus with Graves Disease in a Child.

Shin Hee Kim, Kyung Lim Yoon, Sang Ho Lee, Kyu Yeoun Won, Kye Shik Shim

¹Department of Pediatrics, Kyung Hee University Hospital at Gangdong, Seoul, Korea. 64sks@khnmc.or.kr
²Department of Internal medicine, Kyung Hee University Hospital at Gangdong, Seoul, Korea.
³Department of Pathology, Kyung Hee University Hospital at Gangdong, Seoul, Korea.

Abstract

Autoimmune diseases are occasionally associated with other autoimmune diseases in the same patients. Graves disease has been associated with systemic rheumatic diseases including systemic lupus erythematosus (SLE). The diagnosis of Graves disease in patients with SLE is well known, especially in adults, but few case reports have involved children and adolescents. We report a 14-year-old female who presented with Graves disease, proteinuria, arthralgia, decreased complement, and positive antinuclear antibody and who was diagnosed with SLE. Renal biopsy revealed class IV lupus glomerulonephritis. These clinical, laboratory, and histological findings indicate that class IV lupus nephritis may be associated with Graves disease. This possibility should be borne in mind when following patients with Graves disease in order to avoid any delay in the diagnosis and treatment of serious systemic autoimmune diseases such as SLE.

Keywords: Graves disease;Lupus erythematosus, systemic