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Ann Pediatr Endocrinol Metab > Volume 17(3); 2012 > Article
DOI: https://doi.org/10.6065/apem.2012.17.3.194   
Successful Pamidronate Treatment of Osteogenesis Imperfecta Type III Infant with Multiple Fractures.
Ju Hee Yoon, Jong Uk Baek, Eun Jung Shim, Il Tae Hwang
Department of Pediatrics, Hallym University College of Medicine, Seoul, Korea. ithwang83@hallym.or.kr
Abstract
Osteogenesis imperfect (OI) is a generalized connective tissue disorder. We report the female neonate case with OI type III who showed severe bone deformities and fractures in utero. At birth, she showed multiple fractures in the clavicle, rib, femur, and wormian bone in the skull X-ray. We initiated pamidronate disodium infusion 30 mg/m2 in cycles of 3 consecutive days from when she was 4 days old, monthly for the first 3 months and every 2 months thereafter without adverse effects.
Keywords: Osteogenesis imperfecta;Pamidronate;Bone density;Fractures, bone
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