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Ann Pediatr Endocrinol Metab > Volume 17(4); 2012 > Article
DOI: https://doi.org/10.6065/apem.2012.17.4.249   
Proton-Pump Inhibitor-Induced Hypocalcemia and Hypomagnesemia.
Sae Rom Choi, Jung Hee Byun, Ah Reum Kwon, Ye Jin Kim, Yong Hyuk Kim, Hyun Wook Chae, Ho Seong Kim
Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea. kimho@yuhs.ac
A 7-day-old female neonate who visited emergency depar tment due to generalized tonic seizure. Laboratory test results showed hypocalcemia (5.7 mg/dL), hypomagnesemia (0.55 mmol/L), low parathyroid hormone (7.5 pg/mL), and normal 25(OH) vitamin D3. Symptom and metabolic abnormalities were normalized with intravenous calcium gluconate and magnesium sulfate. Discharged with supplement of oral calcium, vitamin D, phenobarbital, and lansoprazol, she was re-admitted with hypocalcemia (4.8 mg/dL) with normal level of parathyroid hormone (12.3 pg/mL). Hypocalcemia was resolved with discontinuation of proton pump inhibitor. We report a case of recurrent hypocalcemia and hypomagnesemia due to proton-pump inhibitor.
Keywords: Hypoparathyroidism;Proton-pump inhibitors;Hypocalcemia
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