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Ann Pediatr Endocrinol Metab > Volume 3(1); 1998 > Article
Serum Neopterin Concentration in Children with Graves' Disease.
Sung Ho Jung, Moon Young Song, Byung Kyu Shu, Byung Churl Lee
Abstract
PURPOSE
Neopterin is a marker of activation of the T-lymphocyte/monocyte axis. We measured serum neopterin concentration to investigate whether serum neopterin levels are increased in children with Graves' disease and whether serum neopterin measurement can be used as a marker of disease activity in Graves disease. METHODS:Twenty children with Graves' disease(3 boys and 17 girls) and 15 healthy children(7 boys and 8 girls) are enrolled in this study. Serum neopterin concentrations are measured by radioimmunoassay.
RESULTS
Neopterin concentration in children with Graves' disease(1.59+/-1.25ng/ml) is not higher than that of healthy children(1.51+/-0.73ng/ml). Neopterin concentration is not influenced by thyroid function and remission state.
CONCLUSION
Serum neopterin level in children with Graves' disease can not be used as a marker of activity.
Keywords: Graves disease;Neopterin


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