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Ann Pediatr Endocrinol Metab > Volume 5(1); 2000 > Article
Normative Data on Serum Levels of IGF-I, IGFBP-3 in Healthy Korean Children: Effect of Age, Sex, Height, Body Mass Index, and Pubertal Maturation on the Serum Levels.
Jin Kyong Chun, Jae Bok Kim, Han Wook Yoo
Department of Pediatrics, COllege of Medicine, University of Ulsan, Seoul, Korea. hwyoo@www.amc.seoul.kr
Abstract
PURPOSE
This study was undertaken to obtain the normative data on serum levels of IGF-I and IGFBP-3 in healthy Korean children and to evaluate the effects of age, sex, height, body mass index and pubertal maturation on the serum levels of IGF-I and IGFBP-3. METHODS: This study included 301 healthy Korean subjects in pediatric age group. Serum levels of IGF-I and IGFBP-3 were measured twice using IRMA kit in each individual. The correlations between the serum levels of IGF-I or IGFBP-3 and age, auxological data or children's Tanner stages were evaluated.
RESULTS
Serum levels of IGF-I and IGFBP-3 increased in proportion to age progression, and their rates of increase were remarkable shortly before and during the puberty. The correlations between serum levels of IGF-1 and age, sex, height standard deviation scores, BMI, or pubertal maturation were significant(P<0.05). However, the serum levels of IGFBP-3 was correlated only with height standard deviation scores(P<0.05). There was a significant positive correlation between serum levels of IGF-1 and those of IGFBP-3(P<0.001).
CONCLUSION
Although IGF-I and IGFBP-3 assays can be utilized for the evaluation of endogenous growth hormone status, the effects of age, sex, BMI, height and pubertal development on the levels of IGF-I and IGFBP-3 must be considered. Therefore, these results would be helpful as a normative data for the growth evaluation of children in Korea.
Keywords: IGF-I;IGFBP-3;Normative data


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