A Case of Primary Focal Segmental Glomerulosclerosis in an Adolescent Patient with Type 1 Diabetes.

Baek,  Seung Hyon; Kwon,  Ah Reum; Jeong,  Hyeon Joo; Kim,  Min Ju; Chae,  Hyun Wook; Kim,  Ho Seong; Kim,  Duk Hee

Ann Pediatr Endocrinol Metab > Volume 15(3); 2010 > Article

Case Report

Journal of Korean Society of Pediatric Endocrinology 2010;15(3): 203-206.

A Case of Primary Focal Segmental Glomerulosclerosis in an Adolescent Patient with Type 1 Diabetes.

Seung Hyon Baek, Ah Reum Kwon, Hyeon Joo Jeong, Min Ju Kim, Hyun Wook Chae, Ho Seong Kim, Duk Hee Kim

¹Department of Pediatrics, Yonsei University College of Medicine, Korea.
²Department of Pathology, Yonsei University College of Medicine, Korea.
³Department of Pediatrics, Sowha Children's Hospital, Seoul, Korea. dhkim3@yuhs.ac

Abstract

Diabetic nephropathy is a common and serious complication in diabetic patients. Renal diseases other than diabetic nephropathy (non-diabetic nephropathy) can occur in diabetic patients with nephrosis. The presence of non-diabetic nephropathy is noted in type 2 diabetes patients, but no data exists for type 1 diabetes. In this report we describe the case of a 15-year-old girl with type 1 diabetes mellitus, who presented with an acute elevation of urinary microalbumin excretion, general edema, and liver enzyme elevation. She had shown microalbuminuria about 3 years earlier, as well as an uncontrolled hemoglobin A1c level, but she had no diabetic retinopathy and neuropathy. A renal biopsy was conducted, and she was diagnosed with primary focal segmental glomerulosclerosis. She was treated with corticosteroids and an angiotensin converting enzyme inhibitor.

Keywords: Diabetes mellitus, type 1;Diabetic nephropathy;Glomerulosclerosis focal segmental