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Ann Pediatr Endocrinol Metab > Volume 15(3); 2010 > Article
A Case of Primary Focal Segmental Glomerulosclerosis in an Adolescent Patient with Type 1 Diabetes.
Seung Hyon Baek, Ah Reum Kwon, Hyeon Joo Jeong, Min Ju Kim, Hyun Wook Chae, Ho Seong Kim, Duk Hee Kim
1Department of Pediatrics, Yonsei University College of Medicine, Korea.
2Department of Pathology, Yonsei University College of Medicine, Korea.
3Department of Pediatrics, Sowha Children's Hospital, Seoul, Korea. dhkim3@yuhs.ac
Abstract
Diabetic nephropathy is a common and serious complication in diabetic patients. Renal diseases other than diabetic nephropathy (non-diabetic nephropathy) can occur in diabetic patients with nephrosis. The presence of non-diabetic nephropathy is noted in type 2 diabetes patients, but no data exists for type 1 diabetes. In this report we describe the case of a 15-year-old girl with type 1 diabetes mellitus, who presented with an acute elevation of urinary microalbumin excretion, general edema, and liver enzyme elevation. She had shown microalbuminuria about 3 years earlier, as well as an uncontrolled hemoglobin A1c level, but she had no diabetic retinopathy and neuropathy. A renal biopsy was conducted, and she was diagnosed with primary focal segmental glomerulosclerosis. She was treated with corticosteroids and an angiotensin converting enzyme inhibitor.
Keywords: Diabetes mellitus, type 1;Diabetic nephropathy;Glomerulosclerosis focal segmental


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