A Case of Severe Hypertension associated with Growth Hormone Therapy.

Heo,  Nyeon; Oh,  Chang Hee; Huh,  June; Oh,  Phil Soo; Lee,  Hong Jin; Yoon,  Hae Sun

Ann Pediatr Endocrinol Metab > Volume 6(1); 2001 > Article

Case Report

Journal of Korean Society of Pediatric Endocrinology 2001;6(1): 77-84.

A Case of Severe Hypertension associated with Growth Hormone Therapy.

Nyeon Heo, Chang Hee Oh, June Huh, Phil Soo Oh, Hong Jin Lee, Hae Sun Yoon

Abstract

The use of recombinant DNA technology to produce human growth hormone has resulted in a marked increase in availability of Growth Hormone(GH) to treat short stature due to GH deficiency and other conditions, such as Turner syndrome, familial short stature, chronic renal insufficiency and intrauterine growth retardation (IUGR). But, the GH therapy may result in the adverse events such as sodium and water retention, pseudotumor cerebri, slipped capital femoral epiphysis, growth of nevi, recurrence of tumor. We experienced a case of severe hypertension associated with GH therapy in a 14-year-old male who presented high blood pressure up to 190/100 mmHg and normalized at 2-3 weeks after discontinuation of GH. Therefore, we think that the blood pressure should be carefully monitored during GH therapy.

Keywords: Growth hormone therapy;Hypertension;Blood pressure