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Ann Pediatr Endocrinol Metab > Volume 6(1); 2001 > Article
A Case of Van Wyk-Grumbach Syndrome.
Young Dai Kim, Sung Kyun Park, Seung Yang, Jeh Hoon Shin
Abstract
Van Wyk-Grumbach Syndrome is an advanced sexual development in association with primary hypothyroidism. The clinical feature in this syndrome is more consistent with stimulation of the FSH receptor by the markedly elevated TSH levels. Treatment of the hypothyroidism results in a rapid return to normal of the biochemical and clinical manifestations. We experienced a case of Van Wyk-Grumbach Syndrome and report with the brief review of related literature.
Keywords: Van Wyk-Grumbach syndrome;Hypothyroidism;Precocious puberty


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