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Ann Pediatr Endocrinol Metab > Volume 16(1); 2011 > Article
DOI: https://doi.org/10.6065/jkspe.2011.16.1.13   
Analysis of Cytokines in Sera from Type 1 Diabetic Patients at Diagnosis.
In Suk Yoon, Choong Ho Shin, Sei Won Yang
1Department of Pediatrics, Gundan Top Hospital, Incheon, Korea.
2Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea. growth@snu.ac.kr
Abstract
PURPOSE
Diverse cytokines influence the pathogenesis of type 1 diabetes mellitus (T1DM) in different ways. We studied the profile of cytokines in sera from type 1 diabetic patients at diagnosis. METHODS: Serum levels of 11 cytokines (IL-1alpha, IL-1beta, IL-1Ra, IL-2, IL-4, IL-6, IL-10, IL-12 (p70), INF-gamma, and TNF-alpha) from 38 newly-diagnosed T1DM patents and 39 healthy controls were measured, using multiplex immunoanalytic xMAP.
RESULTS
Patients showed significantly higher levels of IL-1beta (P < 0.01), IL-10 (P < 0.01), and TNF-alpha (P = 0.019), than the healthy controls. In 12 of 35 patients, the insulin autoantibody (IAA) was positive (34%) and the level of IAA was correlated with IL-10 (r = 0.454, P = 0.006), and TNF-alpha (r = 0.368, P = 0.030).
CONCLUSION
These results suggest that IL-1beta, TNF-alpha, and IL-10 play a role in the pathogenesis of T1DM, and the level of the IAA is correlated with IL-10 and TNF-alpha.
Keywords: Diabetes mellitus, type 1;Cytokines;Interleukin-1beta;Tumor necrosis factor-alpha;Interleukin-10;Islet cell antibody


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