Case Report

J Korean Soc Pediatr Endocrinol. 2004; 9(1): 81-85.

A Case of Antithyroid Drug-Induced Agranulocytosis Treated with Granulocyte Colony-Stimulating Factor (G-CSF) and Methylprednisolone.

Tae Hoon Eom, Hye Jin Jeoun, Sang Min Cho, Min Ho Jung, Byung Kyu Suh, and Byung Churl Lee

Although rare, agranulocytosis is the most serious, potentially fatal side effect of antithyroid drug. We experienced a 13-year-old girl who developed methimazole-induced agranulocytosis at 1 month after the initiation of treatment. Her granulocyte count recovered after discontinuation of methimazole and treatment with broad spectrum-antibiotics, G-CSF, and methylprednisolone. After recovery from agranulocytosis she was treated with radioiodine ablation therapy. Early detection and proper management of antithyroid drug-induced agranulocytosis is very important.

Keywords : Agranmulocytosis, Methimazole, G-CSF