Warning: fopen(/home/virtual/e-apem/journal/upload/ip_log_2022-01.txt): failed to open stream: Permission denied in /home/virtual/lib/view_data.php on line 73 Warning: fwrite() expects parameter 1 to be resource, boolean given in /home/virtual/lib/view_data.php on line 74 Tailored management of life-threatening complications related to severe obesity in a young adult with Prader-Willi syndrome
J Korean Soc Pediatr Endocrinol Search

CLOSE


Ann Pediatr Endocrinol Metab > Accepted Articles
DOI: https://doi.org/10.6065/apem.2142022.011    [Accepted] Published online October 18, 2021.
Tailored management of life-threatening complications related to severe obesity in a young adult with Prader-Willi syndrome
Min-Sun Kim1, Jiyeon Kim1, Joongbum Cho2, Sung Yoon Cho1  , Dong-Kyu Jin1
1Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
2Department of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Address for correspondence:  Sung Yoon Cho
Email: sungyoon.cho@samsung.com
Received: January 28, 2021   Revised: March 15, 2021   Accepted: March 22, 2021
Abstract
Prader-Willi syndrome (PWS) is characterized by hypotonia, distinctive facial features, hyperphagia, obesity, short stature, hypogonadism, mental retardation, and behavior problems. Uncontrolled hyperphagia can lead to dangerous food-seeking behavior with life-threatening obesity. Severe obesity is prone to obstructive sleep apnea (OSA) and can lead to cor pulmonale. This study reports on a case involving a 21-year-old man with PWS who developed OSA due to severe obesity, leading to cor pulmonale, a life-threatening complication. Multidisciplinary care provided in the intensive care unit included weight reduction, ventilation support, antipsychotics, sedative drugs, rehabilitation, and meticulous skin care. The patient did recover. To prevent severe obesity in adults with PWS, hyperphagia must be controlled and the patient must be managed by an endocrinologist throughout childhood.
Keywords: Prader-Willi syndrome; Hyperphagia; Obesity; Pulmonary Heart Disease; Heart failure; Sleep Apnea, Obstructive


ABOUT
ARTICLE CATEGORY

Browse all articles >

BROWSE ARTICLES
AUTHOR INFORMATION
Editorial Office
#510, DoosanBearstel 381, Gangnam-daero, Seocho-gu, Seoul 06620, Korea
Tel: +82-2-3471-4268    Fax: +82-2-3471-4269    E-mail: kspe.editor@gmail.com                

Copyright © 2022 by Korean Society of Pediatric Endocrinology.

Developed in M2PI

Close layer
prev next