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Ann Pediatr Endocrinol Metab > Volume 8(1); 2003 > Article
Two Cases of Secondary Central Precocious Puberty Occurred in Congenital Adrenal Hyperplasia.
Hye Cheon Jeong, Heon Seok Han
We experienced two cases of congenital adrenal hyperplasia(CAH), complicated by true precocious puberty with early maturation of the hypothalamic-pituitary-gonadal axis in a boy and a girl. The boy was diagnosed as CAH at 8 years of age, when he showed pseudoprecocity with adrenal rest tumor. The girl was diagnosed at neonate, when she showed ambiguous genitalia and salt-losing symptom. They developed precocious puberty during steroid treatment. Clinically they showed precocity, advanced bone age, and decreased predicted adult height, even though they showed partial gonadotrophin response to luteinizing hormone releasing hormone (LHRH) stimulation test. They were treated with LHRH analogue(leuprolide depot) resulting no further progression of precocity.
Keywords: Congenital adrenal hyperplasia;Precocious puberty


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