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Ann Pediatr Endocrinol Metab > Volume 13(1); 2008 > Article
Three Cases of Polycystic Ovary Syndrome Presenting with Hirsutism and Obesity in Adolescence.
Shin Hye Lee, Jung Min Ko, Han Wook Yoo
Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. hwyoo@amc.seoul.kr
Abstract
Polycystic ovary syndrome (PCOS) is characterized by ovulatory dysfunction and hyperandrogenism. It is a complex disorder with multiple components, including infertility, metabolic syndrome, type 2 diabetes mellitus, and cardiovascular diseases. We report three cases of PCOS presenting with hirsutism and obesity in adolescence. They showed hirsutism, acne and acanthosis nigricans, and obesity with the body mass index above the ninety-fifth percentile for their age and sex matched reference values. Laboratory findings showed elevated luteinizing hormone, total testosterone and decreased sex hormone binding globulin. One patient was diagnosed as having impaired glucose tolerance by oral glucose tolerance test, and three patients showed insulin resistance classified by homeostasis model assessment-insulin resistance (HOMA-IR) value. All patients were treated with exercise, low calorie diet. And metformin and estrogen- progesterone oral contraceptives were administered in two of three patients, respectively. During the follow-up period, two patients have achieved weight loss and recovered regular menstruation.
Keywords: Polycystic ovary syndrome;Hirsutism;Obesity;Adolescent


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