| Changes in High Levels of 17 alpha-Hydroxyprogesterone at Neonatal Screening. |
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Eun Young Park, Jin Hyung Cho, Su Jin Lee, Seung Yang, Kwang Nam Kim, Jeh Hoon Shin, Phil Soo Oh |
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| Abstract |
PURPOSE
There are some cases of false positive in neonatal screening for congenital adrenal hyperplasia. To understand its significance of the increased 17 alpha-hydroxyprogesterone(17 alpha-OHP) levels in the cases of positive result, we followed its levels during infancy.
METHODS:From July 1997 to June 1998, totally 1,730 babies were screened for congenital adrenal hyperplasia(CAH) measuring 17 alpha-hydroxyprogesterone(17 alpha- OHP) using an enzyme immunoassay(EIA) on dried blood spots. In infants of positive result, the radioimmunoassay(RIA) was used measuring 17 alpha-OHP in serum. And we followed up the levels of 17 alpha-OHP during infancy. Cortisol and ACTH were also measured and followed up in the morning simultaneously.
RESULTS
No CAH was detected during the study period. With the 13 ng/mL cutoff limit for 17 alpha-OHP before March 1998, the recall rate was 3.09%. With the 20 ng/mL cutoff limit after March 1998, the recall rate was decreased to 1.58%. Follow-up of the high levels of 17 alpha-OHP in positive cases showed a sharply decreased curve according to age.
CONCLUSION
In clinically normal neonates, the high levels of 17 alpha-OHP at screening decreased continuously during infancy. |
| Keywords:
Neonatal screening;Congenital adrenal hyperplasia;17 alpha--Hydroxyprogesterone(OHP);Cut-off limit |
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