Prediction of 1 Year Growth in Girls with Precocious Puberty with GnRH Agonist Treatment by Measurement of Growth Velocity at 3 Months after Treatment.

Shin,  Jung Hee; Hu,  Won Kyung; Hwang,  Il Tae; Yang,  Seung

doi:2011.16.2.80

Ann Pediatr Endocrinol Metab > Volume 16(2); 2011 > Article

Original Article

Journal of Korean Society of Pediatric Endocrinology 2011;16(2): 80-85.

DOI: https://doi.org/10.6065/jkspe.2011.16.2.80

Prediction of 1 Year Growth in Girls with Precocious Puberty with GnRH Agonist Treatment by Measurement of Growth Velocity at 3 Months after Treatment.

Jung Hee Shin, Won Kyung Hu, Il Tae Hwang, Seung Yang

Department of Pediatrics, Hallym University College of Medicine, Seoul, Korea. drsyang@hallym.or.kr

Abstract

PURPOSE
The aim of this study was to assess the usefulness of growth velocity at 3 months after gonadotropinreleasing hormone (GnRH) agonist treatment as a predictive value of 1 year growth velocity after treatment in girls with precocious puberty. METHODS: We studied 30 Korean girls with precocious puberty whose chronologic and bone age were less than 9 years and 11 years old, respectively at diagnosis. They treated with a 4 week interval GnRH agonist subcutaneous injections for at least more than 1 year. The patients who were treated with growth hormone simultaneously excluded for this study. Data were collected from chart review retrospectively. We measured heights and calculated growth velocities of the subjects at 3 months and 1 year after GnRH agonist treatment.
RESULTS
The mean chronologic age and bone age of the subjects were 8.3 +/- 0.8 year and 10.4 +/- 0.6 years, respectively. The growth velocity at 3 months, 6 months, 9 months and 1 year after GnRH agonist treatment were 7.1 +/- 2.6, 6.6 +/- 2.1, 5.7 +/- 1.3 and 5.8 +/- 0.9 cm/yr, respectively. The positive correlation between the growth velocity at 3 months and 6 months, 9 months, 1 year after GnRH agonist treatment were shown(P < 0.001, P < 0.001, P = 0.002, respectively).
CONCLUSION
In this study, the growth velocity at 1 year after GnRH agonist treatment may be predicted by the growth velocity at 3 months after treatment. The patient whose growth velocity at 3 months after GnRH agnoist treatment was low would be needed to observe the growth pattern carefully and to consider combined growth hormone treatment, if needed. It may be deserve further studies to improve final height in patients with central precocious puberty in various conditions.

Keywords: Growth;Sexual precocity;Gonadotropin releasing hormone agonist